C-CAMP has emerged as a thriving hub for innovation with a vibrant ecosystem. We have interacted with over 500 inventors and entrepreneurs and encouraged them to translate their inventions into innovation. Till date C-CAMP has supported over 100 start-ups/spin-offs through funding, bio-incubation and mentorship.
Achira Labs is a Bangalore-based start-up whose primary focus is the development of a proprietary lab-on-chip platform to perform rapid, quantitative and multiplexed immunoassays. Their innovative Fabchip platform uses existing expertise and capital infrastructure available in the handloom textile industry to manufacture biological sensors using woven fabric. Their first product ACIX-100 is a proprietary platform that has been calibrated to perform POC tests for HCG (pregnancy), thyroid hormones, and female fertility hormones. Achira has procured follow-on funding from Catamaran Ventures. They are also funded by IGSTC, ICMR, and Grand Challenges Canada.
Bagmo is a Bangalore-based start-up working towards addressing issues of poor blood transfusion facilities in rural areas in India. Their first product is a novel blood bag monitoring solution while blood is being transported to rural areas. Blood storage centres (BSCs) address the issue of blood availability to most of the remote locations in India. Bagmo is developing a networked smart temperature tracking system for blood bags. Each blood product (blood bag) comes with a unique radiofrequency identity (RFID) and every BSC storage units has a RFID scanner and efficient, smart temperature sensors. The proposed solution will ensure reliability of blood products.
The wet labs for Cellworks Research India Ltd was working at C-CAMP to validate the bacterial virtual platforms that aid therapeutic product design. Cellworks is a biopharmaceutical therapeutic design and development company based on platform predicting clinical outcomes. The project was focused on building the labs abilities to identify and grade chemically vulnerable targets for anti-infectives and develop mechanism-biased drug screening assays.
Coeo Labs is a young med-tech start-up focused on innovative medical devices for Emergency, Trauma and Critical Care. The medical device start-up, has developed VAPCare which is a complete tracheal secretion management device. It is embedded with sensors and removes secretions from three different locations in the oral cavity and trachea, thus preventing micro-organism entering the lungs, which causes Ventilator Associated Pneumonia (VAP). Coeo was able to test full functionality of the product using an airway mannequin. This is the only device in market which can do automated oral hygiene and secretion management. The proprietary sensing techniques sense the secretion and manage it. It also takes care of oral hygiene and prevents VAP. Coeo has raised follow-on funding from several sources and their product is ready for launch.
df3d is a Bangalore-based startup focused on developing a platform technology for healthcare solutions using 3D printed medical models and customized 3D printed surgical guides. At Osteo3d, they enable maxillofacial, cranial and orthopaedic surgeons to leverage 3d printing and increase accuracy and reduce lead time of surgical procedures by means of 3d printed medical models and 3d printed surgical guides and implants. They have launched their product and are generating revenue. They have secured follow-on funding from GO Idea2POC scheme.
Empathy Design Labs
Empathy Design Labs is a Bangalore-based company working on developing a fetal monitoring device to prevent still births in developing countries. As per WHO report - 2.6 million stillbirths take place every year across the globe. More than 98% of these still births occur in developing countries like India. Empathy is designing a device to prevent stillbirths in developing countries by introducing an affordable, wearable, effective, and non-invasive screening and monitoring tool. Post completing early clinical studies, they plan to introduce the product into the Indian market in late 2018.
Indio Labs was founded by an alumnus of the Stanford-India Biodesign Program. This company is developing platform technology devices for soft tissue core biopsy (BioScoop™) and BxSeal™ technology for controlled, concurrent delivery of hemostatic agents during the biopsy procedure. In addition, their handheld device would perform automated cytometric analysis, and display the quantitative results on its screen; thereby totally eliminating the need for having a skilled personnel as well as laboratory resources to conduct these diagnostics. They have completed the design and development activities, created intellectual property, and have extended the device for all soft organ biopsy. They have also raised follow-on funding.
InnAccel Acceleration Services
InnAccel Acceleration Services is India's first medical technology acceleration company focused on innovation for low and mid-income markets. Dr. Jagdish Chaturvedi is the director of Clinical Innovation at Innaccel and leads the development of affordable medical devices for the company. He leads a team working on a technology called Noxeno, which is a novel, dedicated, easy to use device for effective removal of impacted foreign bodies (NFB) from the nasal cavity in children by GPs and/or health workers in underserved areas. Noxeno was launched recently. Another product, Sinucare - a balloon sinuplasty device for sinusitis, has been launched. They have recently started generating revenue and have secured follow-on funding.
Jiva Sciences Pvt. Ltd.
Jiva Sciences Pvt. Ltd. is a start-up working in the area of microfluidics and lab automation, currently developing solutions in the area of animal and human cell type identification. Their current focus is in the following areas:
1. Microfluidics & Photonics based Cell Sorting
2. Microfluidics & Photonics based Point-of-Care Diagnostics
3. Lab Automation
Their primary focus as an organization is in tune with the “Make in India” objective, through focusing on building hardware that can contribute towards issues of national importance as well as fit the technical dearth in our country.
Mimyk is a spin-off from the Indian Institute of Science (IISc), Bengaluru. They work on developing immersive medical simulation technologies. They combine hardware and Software to build next-gen simulation platforms. The current focus at Mimyk is an endoscopy simulation platform. Mimyk’s technology is developed through a collaborative research and development activity carried out at the M2D2 Lab, IISc and the Visualization and Graphics Lab (VGL), IISc. We are incubated at the Society for Innovation and Development (SID), IISc. They have secured follow-on funding from the ELEVATE100 scheme of Govt. of Karnataka.
Module Innovations is a Pune-based company developing strip-based biosensors for the detection of E. coli in food and clinical samples. Module envisions to bring healthcare parity by making systems which can detect diseases at the point of care, without needing a laboratory, trained manpower, electricity and easy to interpret results with colorimetric readouts. Their product portfolio currently includes three devices: EcoSense (for E. coli detection), Usense (detection of specific Uropathogens) and Csense (screening of cervical cancer). They have raised follow-on funding from several sources.
Nesa Medtech is a medical device start-up working towards excellence in the Research & Development of Medical devices. They are developing an accessible, minimally invasive procedure to treat symptomatic uterine fibroids safely and effectively. Uterine fibroids are very common non-cancerous growths that develop in the muscular wall of the uterus. Nesa proposes to develop a minimally-invasive device for in-office use to treat symptomatic uterine fibroids. This can be achieved by ablating fibroids using a radio frequency electrode inserted through the uterine cavity under local anesthesia with real-time guidance through a trans-vaginal ultrasound. They have secured follow-on funding from GOK through the Idea2POC scheme.
NextGen Invitro Diagnostics Pvt. Ltd.
NextGen Invitro Diagnostics Pvt. Ltd. is a Delhi based start-up and a C-CAMP incubatee that takes up Research Process and developed products areas of novel and point of care diagnostics. Their business model is to develop and commercialize state of the art diagnostics. They have several Indian and International collaborations for Licensing better diagnostics. They have solutions for Point Of Care and multiplexing disease diagnosis platform for Tuberculosis, Malaria and Leishmaniasis.
Oreva Medicare Research Pvt Ltd.
Oreva Medicare Research Pvt Ltd. works on a hands free "electronic larynx" which is affordable, aesthetic in appearance with near normal sound quality. It is also working on an alaryngeal speech device to provide near normal speech for laryngectomee patients. Their proposed solution is conceptualized as an affordable device that would have functions of pitch adjustment and variation together with loudness, producing near normal voice. The device would enable the user to operate mobile phones, microphones and other electronic devices. The device would have a hands free design with decreased radiated noise and better cosmetic acceptability. Their product is aimed to be an affordable way to non-surgically rehabilitate patients who have undergone laryngectomy to restore near normal voice.
Prantae is a Bhubaneshwar-based start-up working on the development of a diagnostic platform for the miR-based detection of pre-eclampsia. Pre-eclampsia (PE) is one of top four causes of maternal deaths during pregnancy. Prantae proposes to translate the potential of identified miRs into an affordable clinical platform for early prediction of PE. They aim to develop a plasmonic biosensor detection optical unit capable of measuring a specially engineered gold nanoparticle based biosensor harboring a DNA probe specific to PE miR. The proposed innovation is expected to have a significant socio-economic impact. Early diagnosis of PE not only ensures timely intervention during pregnancy but also will impact the expenditure on the neonatal care due to PE induced pre-term emergency deliveries.
Scidogma Research is a Bangalore-based company that develops cost-effective medical technology to serve low-resource settings. Their first product- CNC microscope – an automated microscope that provides a platform for Artificial Intelligence and Machine Learning, for disease diagnosis. It’s a portable device with a compact lens system and image capturing features. It has been successfully designed for malaria diagnosis and can be used in remote areas in developing countries where healthcare sector is still underdeveloped. CNC microscope is revolutionary in microscopic based diagnosis. Further, it has features to share the images through cloud for further analysis and real time monitoring of outbreaks.
Sensivision is a young start-up that focuses on finding innovative and affordable medical device solutions for Neonatal health challenges and is currently engaged in developing a device for treating Hypoxic Ischemic Encephalopathy, a complication of Asphyxia in Neonates. Sensivision’s solution, REVIVE, will be a comprehensive HIE management system with treatment, diagnosis and prognostication integrated on a single device. The product is currently in the final stages of prototyping.
Shanmukha Innovations intends to develop an imaging-based point-of-care diagnostic device, which can fully-automate the complete work flow of conventional clinical microscopy. He is incubated at the Robert Bosch Center for Cyber Physical Systems (RBCCPS), IISc. A custom designed portable digital microscope augmented with dedicated microfluidic lab-on-chips would enable process automation, as well as, cost-effective implementation of microscopic diagnosis of malaria. Such an inexpensive, portable, and easy-to-use diagnostic device is expected to greatly enhance the quality of health-care available to the rural population of the world.
Shilps Sciences is a Bangalore-based start-up focused on harnessing the power of nanotechnology instruments to solve problems in healthcare. They are an developing Atomic Force Microscope and micro-fluidic technologies for isolating single cells for applications in Life Sciences. Shilps Sciences has developed a novel microfluidic technology to isolate and arrange cells. They are now combining this with an Atomic Force Microscope for cancer diagnostics. The company has created IP, built prototype demonstrators and is in an advanced stage of product development. They have ongoing collaborations with cancer labs.
Spotsense in a resident incubate at C-CAMP. It is currently working towards creating simple affordable and accessible diagnostics especially in the field of pediatric medicine. Spittle, the first product by Spotsense is a diagnostic pacifier which has been developed as a platform for saliva based screening of various neonatal health ailments. The first offering on this platform is a rapid diagnostic test for Neonatal Sepsis. The product is currently in prototype stage and expected to be in market by 2018.
Strand Lifesciences: C-CAMP was incubating this BIPP funded Strand life science project initially. Strand Lifesciences focuses on data mining, predictive modeling, computational chemistry, software engineering, bioinformatics, and research biology to develop software and services for life sciences research. At C-CAMP a group from Strand worked on clinical genomics and hepatotoxicity prediction platforms.
Siamaf healthcare is a young start-up incubated at the Society for Innovation and Development (SID), Indian Institute of Science. The company is led by Dr. Subhasis Sarangi. The company is currently working on developing a new method of detecting how far a patient’s cancer has spread. The device works on pulse induction principle and uses magnetic nanoparticles for sentinel lymph node biopsy procedure, rather than the standard radioactive isotopes and blue dye, which improves safety, accessibility, and reduces treatment cost.
Unilumen Photonics is a young venture currently incubated at IIT Madras that specializes in the manufacture of fibre laser systems. By partnering with key research institutions across India, they aim to develop solutions that address the biomedical and bioimaging needs of our society. The product portfolio includes pulsed and CW fibre laser with low, medium and high power optical fibre lasers. Unilumen’s BM series Bio medical laser product is capable of delivering high power optical pulses suitable for photo selective vaporization of prostate tissues, retinal photocoagulation, dental bleaching, treatment of facial vessels and a broad range of clinical applications. They have commercialized their fiber laser products and have started generating revenue. They have also raised private funding for their venture.
Terrablue XT is a Bangalore-based company working on technologies to monitor mental health and manage epilepsy. TerraBlue XT’s portfolio includes TJay, an award winning device for the prediction, detection and management of people with epilepsy. TJay catapulted the company to fame, when it became one of the top three winners of the Innovate for Digital India Challenge in 2015, supported by Intel and Government of India that saw participation for 1900+ startups and individuals. TJay was quickly followed by Xaant, a wearable that helps practice calm, gives intriguing insights about the state of a person’s mind and shows how to beat stress. With its ability to understand mental health quickly, Xaant, currently in the final prototype stage, is expected to create waves in the wellness sector and is poised for release in the global market.
Yostra Labs is a healthcare technology firm pioneering smart innovations to make healthcare more effective, affordable and sustainable for the cost sensitive developing market. Their key focus area is Diabetic Care, with two products on the anvil. They are developing a market-viable Diabetic Peripheral Neuropathy screening device called ‘Sparsh’ that makes screening of diabetic patients more accessible and affordable to patients of all socio-economic strata. Yostra is also working on a device for the treatment of Diabetic Foot Ulcer – Kadam, which enables faster healing of chronic ulcers. They have secured follow-on funding from the Idea2POC scheme from GOK.
Tejomir Diagnostics LLP
Dr. Kalyani is a molecular biologist with a Ph.D. from Johns Hopkins University, USA. She is developing an affordable, point of care device for comprehensive and early detection of liver disease. Current diagnostics for detection of alcoholic and non-alcoholic liver disease are neither comprehensive nor accurate for all situations and add to increasing costs for patients. Her project will build a technology device utilizing biomarkers miRNA in blood to detect liver disease much earlier, more comprehensively and at an affordable cost bringing clarity and certainty to diagnosis. The goal is to build a point of care device for easy use, eliminating the necessity for trained personnel and laboratories. Successful adoption of the technology will transform the current market, introducing a blood based diagnostic equivalent to the gold standard biopsy.
Dr. Prasanth Rathinam
Dr. Prasanth Rathinam is an individual entrepreneur working on biofilm associated medical device to prevent urinary tract infection. Prashanth received his Doctoral degree from VIT University, Vellore in Renal diseases (Especially Nosocomial Infections). His research interests include cell-cell communication in pathogens/anti-virulence mechanisms/Devise associated nosocomial infections/Biologically improved devises. He is currently working on biofilm associated medical device infections and with the help of the BIG fund he would like to upend the currently available infection prone urinary catheters to anti-infective.
Qawach Bio Pvt Ltd
Dr. Rashmi Tambe is working towards the development of a device for the early detection of acute and chronic kidney diseases. Almost 30 pct. of all hospital admissions fall in a wide definition of Acute Kidney injury [AKI] and 10 pct. of population worldwide is affected by Chronic Kidney Disease [CKD]. Among the most recent biomarkers suggested for AKI, the molecule called Neutrophil Gelatinase-Associated Lipocalin [NGAL] was found to be suddenly up-regulated during the early stages of renal injury. In contrast to traditional markers like SCr, this rapid response enables NGAL to potentially identify kidney injury at a much earlier stage. Rashmi proposes to develop an affordable and non-invasive point-of-care [POC] device that can detect an increase in the levels of NGAL in patients susceptible to renal injury.
Sepio Health Pvt. Ltd.
Dr. Praveen Vemula is developing novel biomaterials to solve unmet clinical needs. Currently, he is developing a dermal cream to prevent chronic pesticide exposure in farmers. He has generated stellar preclinical data using our technology. He has two formulations to prevent pesticide-induced toxicity. He has developed a dermal/topical gel to prevent dermal exposure of MPT. Additionally, he is developing an active face mask which can deactivate pesticides to prevent pesticide-exposure through nasal route.
Mocxa Health Pvt Ltd
Raja Aditya Kadambi, one of the co-founder, holds a Master's degree in Computer Engineering from the University of Florida - Gainesville and Bachelor's degree in Engineering from National Institute of Technology – Surat with a background in video technologies and medical imaging. MOCXA Health is developing the world's first completely automated Video-EEG system for accurate diagnosis of seizures named 360evs. Using advanced video and image processing, modern sensors and mobile technologies, this system makes seizure diagnosis more accurate, automated, affordable and accessible.
Neospec Labs are developing a point of care, handheld Bilirubin Meter for accurate detection of jaundice in Neonates. They use direct spectrophotometric principles combined with concepts of biochemistry at the core of their product. The advantages of this method are speed, elimination of centrifugation or other sample preparation, and instrument portability among others.
Cartosense is a medical device startup building products that enable neurosurgeons to plan and safely perform brain surgery through the smallest openings in the skull. Their proprietary technology platform – small form-factor high-accuracy tracking of surgical instruments combined with novel algorithms and workflow improvements – makes high-end surgical navigation compact and affordable for emerging markets. They are also building next gen augmented reality surgical guidance systems that provide the surgeon with tools to visualize, plan and execute small openings and narrow operating corridors with unprecedented spatial understanding, leading to lower postoperative complications, reduced hospitalization time and reduced treatment costs for patients and caregivers.
Kyntox Biotech Pvt Ltd
Kyntox Biotech founded by Gopi Kadiyala developing a Rapid Point-Of-Care Test Kit to Identify the Bitten Snake Species so that specific anti-snake venom can be used in treatment of snake bite.
Morphle Labs Pvt Ltd
Morphle Labs is a Bangalore-based start-up incorporated with a vision to improve the lives of Patients and Healthcare Providers by enabling better diagnostic outcomes at an affordable cost. They operate in the domain of Digital Pathology and In-Vitro diagnostics and provide Products, Software and Solution to improve the efficiency and effectiveness of pathology workflows. They believe that simple digitizing will unlock great potential spanning across effective tele-reporting and powerful computer vision aided tools.
RCupe Life Sciences Pvt Ltd
RCupe Lifesciences Pvt Ltd is a Medical Device Company focused on innovative solutions in the field of critical care. The product portfolio includes 1. Cardiopulmonary resuscitation device, a solution for patients with sudden cardiac arrest and 2. Ozyn-D Intraosseous device, a solution for difficult intravenous access.
Muse Diagnostics Pvt Ltd
MUSE Diagnostics is a Bangalore based medical device company founded by Arvind Badrinarayanan & Sumukh Mysore. MUSE is currently working on a futuristic digital stethoscope called TAAL that aims to solve a latent crisis in the medical world. 80% of human death is caused by respiratory and cardiovascular disorders, most of which go undetected due to the lack of screening tools and inconsistent storage of medical data. MUSE's Digital Stethoscope called TAAL, collects sound waves and analyses them across a database of defective medical conditions to provide an affordable yet innovative answer to this global problem. TAAL is loaded with a patented electronic and acoustic design, that makes it robust, portable and easy to use. Features like volume control, multiple filter modes for heart, lungs and bowel sounds, with a 3.5 mm audio output and magnetic charging puts TAAL in a competitive position in the global market.
Althion Tech Innovations Pvt Ltd
Althion is a health-tech startup developing import-substituting medical/healthcare equipment & devices for India, and eventually the rest of the developing world.
Althion has licensed a patented technology developed by CSIR Indian Institute of Chemical Technology. Building upon this, they are developing two products addressing unmet needs in the Type-1 ultrapure water industry and hemodialysis space respectively. For hemodialysis Althion has developed a low maintenance IoT connected pure water unit that can be remotely monitored and thereby prevent unexpected breakdowns that affect patient care.
Dr Haripriya Sumana
Dr. Haripriya Sumana is a practicing Consulting General Physician, Diabetologist and Innovator of Advanced Prosthetic Devices for Above knee and Below knee Amputees. Dr. Haripriya's inventions involve novel light weight prosthetic devices involving advanced carbon fiber technology and has 3 Provisional patents with the Indian Patent Office presently. These novel Prosthetic Devices involve unique "double heel system", "light-weight pyramidal composite" and "intralayer reinforcement" which addresses the unmet needs for a smooth transition for patients, elimination of heavy metallic connectors and fittings, thereby offering mid-stance stability and improved comfort to amputees.
Svasthyaadhar Pvt Ltd
Co-founded by Dr. H N Suma is majorly into Bio-medical research and is working/worked as PI for various funded projects to the tune of 180 Lakhs majorly in the field of Medical device development. Her Research Interests are: Medical Imaging, Brain Mapping, Neural Networks, Pattern recognition and Affordable medical device development. Under the BIG scheme, she is developing a technology to provide timely help and first aid to accident or mass disaster victims with secure and safe transport to Hospital without waiting for ambulance. She is building a comprehensive and affordable medical trauma kit that can cater to the emergent needs of the accident victims and ensure safe and rapid transport of such persons to the nearest healthcare facility for definitive treatment.
Carditek Medical Devices Pvt. Ltd.
A revolutionary way to improve the cardiac care. Carditek provide a complete solution for monitoring electrical activity of the heart, from acquisition to cloud computing, artificial intelligence for eventually higher accuracy in automation, human analysis in a back office. Also, eliminate the need for young doctors and family physicians to be proficient in ECG’s with this device. No training is needed for doing the ECGs and no training report as this will be taken care of in the back office, with a turnaround time of less than 3 minutes.
Dr Balasubramanian Natarajan
Dr. Balasubramanian Natarajan an entrepreneur bringing his 15 years of academic and industrial experience in the diagnostics platforms. He is interested in the Diagnosis of invasive fungal infections in immunocompromised patients admitted under critical care settings. Under the BIG grant, he is developing a culture independent; multiplex PCR that detect 18 different invasive fungi directly from a clinical specimen in a single test. The multiplex PCR amplifies virulent specific genes, which encompasses clinically relevant 18 invasive fungal pathogens including 11 different species from clinical relevant Candida genus to identify amplified products using organism specific probe by hybridization. The final end readouts are obtained by employing Up-Converting nanoparticles (UCNP) - detection system known for its high sensitivity and specificity with a proposed sample turnaround time of 7 hrs.
Autoyos Private Limited
Autoyos Private Limited, a Bengaluru based DeepTech medical device company co-founded by Dr. Bharat Kumar Hegde and Vijayashri Nagavi specializes in autonomous medical systems. Autoyos offer comprehensive eye care delivery in non-clinical or resource-poor settings without depending on special infrastructure or skilled manpower. Under BIG grant, Autoyos proposed to develop a comprehensive diagnostic device for the dry eye disease detection, which is an affordable and non-contact and a smart diagnostic tool by combining multiple methods in one device. The solution will be a closed loop dry eye care eco-system to enable the needy population to avail required care with the help of intelligent telemedicine environment.
Dr Deevish N.D.
Dr. Deevish is an entrepreneur cum plastic surgeon having keen interest in developing new medical devices related to wound care. As a fellow at Stanford India Biodesign Fellow 2014, co-innovated several medical devices with different teams, which are now at different stages of development and manufacturing. Currently, working on a device for rapid healing of chronic wounds and burns using epidermal autografts. He proposed to develop a product - Epiclose, is a disposable, easy to use standalone device to produce epidermal autograft embedded dressing which can be directly applied over the wounds to achieve faster healing. It also eliminates the need for prolonged dressings as well as surgical skin graft procedure. With faster healed wounds, patients will be able to lead a normal life once again.
SkyFire Applied Intelligence Pvt. Ltd
Atom360 (registered as SkyFire Applied Intelligence Pvt. Ltd), a Bengaluru based startup co-founded by Mr. Reuben Fernandes, is an AI-enabled healthcare solution provider using state-of-the-art technologies to develop economical, accessible, and reliable screening solutions by employing technologies such as Artificial Intelligence. At present, developing an Artificial Intelligence algorithm which will run on smartphones. The algorithm will be used to identify potentially malignant disorders like precancerous and cancerous oral lesions by analysing images captured by the smartphone's camera. Through accessible early detection and treatment, it is possible to reduce treatment costs by at least 20x and treatment time from the current 3 months to less than 10 days while also saving the lives of patients.
Mr. Tanmay Sutaria is an entrepreneur and industry veteran with over 20yrs of cross disciplinary experience in design and manufacturing of Medical Electronics, Control Systems and software systems based out of Ahmedabad. He proposed to aims to design and develop a fully indigenous, State of the Art Peristaltic Intravenous Infusion Pump with Communication/IoT Interfaces customized to Indian requirements with the goal of improving basic Clinical Care Standards and Nursing Efficiency at all healthcare levels.
Sirfbio Pvt. Ltd
Sirfbio Pvt Ltd is a startup based at Hyderabad co-founded by Mr. Suresh Ganjanan Patwardhan which is involved in Manufacture of medical appliances and instruments and appliances for measuring, checking, testing, navigating and other purposes except optical instruments. Under BIG, they are developing an integrated Real Time PCR combining the isolation, amplification and detection in a single platform along with automated DNA extraction. Proposed equipment being an open system various amplification reagents for specific infections like Malaria, TB, Leishmania can be designed, which can be implemented in rural dispensaries. The proposed equipment can have many more applications for detections of infections in aquaculture, GMO detection in agriculture and infections in veterinary and small animals.
nWarehouse is a creative start-up founded by Dr. Manivannan Doraipandian, a professor turned entrepreneur from SASTRA University, Thanjavur. The company stands for quality assessment, prediction, and system development. It facilitates the client’s business models to achieve their target using the current IoT technologies and resources. He proposed to establish IoT network framework to monitor organoleptic properties and the spoilage biomarker of paddy. Also, it can collect dataset from various food grain silos at different environmental conditions via cloud and predict the spoilage using the edge analytical model which is entirely controlled via an mobile app. This product can avoid food grain wastage in storage spaces and to assist in various stages of supply chain. The proposed IoT node with network infrastructure features facilitates online monitoring of food godowns with novel custom developed decision-making algorithm.
Lifespark Technologies Pvt. Ltd.
Lifespark Technologies is a young startup co-founded by Amey Desai specializing in curated solutions for Parkinson's disease. Their solutions help those with Parkinson's live a more independent life and in turn connect patients and their families with medical professionals and caregivers for the extended medical care. They propose to create a non-invasive, wearable device based on Artificial Intelligence and Augmented Reality to reduce gait deficiencies in Parkinson’s Disease patients. The system will be based on the well-established concept of sensory cueing, where certain audio-visual stimuli help patients improve gait and overcome freezing episodes. Therapies such as sensory cueing can complement standard drug therapies and do not reduce in efficiency over time. Cue-based therapy has been shown to produce significant improvement in gait.
Accord Innovations Pvt. Ltd
Dilip S is a BIRAC Social Innovator, C-CAMP and Founder of Accord Innovations Pvt Ltd developing a predictive technology platform for the early detection of critical illnesses. AKICare device is a novel non-invasive attachment to any traditional urinary Foley catheter, provides a new diagnostic tool for real-time & accurate measurement to monitor kidney function and alerting to clinicians to detect the onset of AKI during ICU stay and major surgery to intervene & prevent AKI & thousands of avoidable deaths. AKICare also provides active urine tube drain line clearance with finer measurement intervals on minute to minute variability that continuously measures urine flow rate, episodes of oliguria, along with other real-time vital signs like hydration status & Urinary oxygen tension (renal hypoxia) to indicates the early onset of AKI.
Vnir Biotechnologies Pvt. Ltd
Vnir Biotechnologies Pvt Ltd is spin-off from Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore. They are aiming to become global leaders in red/near infra-red fluorescence detection. They offer fluorescence molecule to fill the gaps that have not been addressed so far - DNA, reactive oxygen species, mitochondria detection at high efficiencies. Diagnostic kits and devices which can detect Alzheimer’s, malaria, kidney failure at an early stage are in development. Under the BIG grant, they propose to develop kits for high fidelity collection of cfDNA from blood samples with applications in screening for cancer markers and fetal disorder markers.
Mercuri Biotechnologies Pvt. Ltd
Mercuri Biotechnologies is a young Bangalore-based start-up that is developing a novel assay for DNA quantitation. In the conventional systems, quantifying the concentration of DNA and differentiation based on size requires two separate instruments, i.e., UV spectrophotometer and agarose gel electrophoresis. UV Spectrophotometer by itself cannot differentiate the size of DNA and is quite expensive. Mercuri proposes to develop a novel technology delta-nuQleo which can simultaneously differentiate band size and provide concentration of the DNA sample instantly in the form of a digital gel. This technology uses the electrical property, capacitance, for measuring the concentration and length of the nucleic acid. Their technology is cost-effective, with added benefits of no reagents or consumables, no waiting time and only the instrument cost.
Sedign Solutions Pvt. Ltd
Sedign Solutions Pvt. Ltd, a startup based at Bengaluru is a process-led innovation company aimed at proactively identifying gaps that affect users and work with relevant stakeholders to design and diffuse solutions. They believe in following a structured process for need identification, research, ideation, prototyping and diffusion. They are developing a technology for the filtration systems to reduce the clogging of membranes and thus, enhance the filtration efficiency for the ESRD patients undergoing dialysis. The technology has applications in blood dialysis where it can improve the quality of treatment for the patients and reduce costs. In the RO water purification systems, the technology can reduce the amount of rejected water and the need for frequent servicing.
Rajesh Laboratories Pvt. Ltd
Rajesh Laboratories is a national award-winning innovative hardware and devices start-up based in Bangalore working primarily on affordable medical devices and cutting-edge technologies. Dr. Rajesh P is the founder, MD and CEO of the company. He is a physician, innovator, entrepreneur, and chief designer who leads the innovations at Rajesh Labs. They are developing an economical, safe, hand-held medical diagnostic device that can diagnose multiple diseases and medical conditions to meet the healthcare needs in underdeveloped and developing countries.
Yogee's Bioinnovations Pvt. Ltd
Yogee’S Bioinnovations is a BITS-PILANI faculty led start-up based out of Hyderabad working on innovative technologies for cancer therapeutics, non-invasive cancer diagnosis and nutrition and immune boosting products. The company has 3 Indian patents and 6 international patent applications over the last 5 years. They are working on the product iCanO (I can Know, a portable medical device to detect multiple cancers using saliva for both diagnosis and prognosis. Their one saliva test can detect multiple cancers and could be used for prognosis of cancer treatment.
Eikona X Innovative Solutions Pvt. Ltd
Eikona X Innovative Solutions is a product-based company working in the domain of Healthcare with specific interest in dental innovations incubated at Manipal-GoK Bioincubator, Manipal. They are developing a novel, easy to sue clip-on-device to take dental radiographs in a faster, easier and better way. It will reduce the need to take repeat radiographs thereby drastically reducing unnecessary radiation exposure to the patient.
Dr Prashantha Thankachan
Prasanth T is a medical physiologist with a keen interest in the functional and operational interaction of the human physiology and also understands engineering and technological capabilities to solve complex medical issues using simple approach. Their team is working to develop a prototype of an indigenous Left ventricular assist device by integrating the micro brushless motor technology with a human cardiac function for the end stage cardiac failure patients. It would be 100% made in India and at par in technology, size and function with the currently available but imported LVAD for use in Indian patients and also to keep the end cost to be below 10% of the currently available LVAD.
Dr Deval Karia
Deval Karia is a graduate of the M. Des. program at CPDM, IISc, Bengaluru where he was awarded the Gandhian Young Technological Innovator (GYTI) award. He is developing a novel, affordable insulin pump for T1DM patients, comparable to a commercially available pump, while bringing down the cost by an order of magnitude. The device works on the syringe pump principle, wherein controlled movement of a plunger within a syringe dispenses the desired volume of drug. This movement is achieved via a novel mechanism that converts continuous rotary input of a motor to linear output. Patient input of the desired drug volume, in turn drives the motor rotation. The Insulin reservoir (essentially a disposable syringe) is housed within the pump and is connected to an infusion set. The infusion set delivers the drug to the patient via a cannula (a thin tube inserted into the patient’s subcutaneous tissue). The reservoir and set constitute the delivery pathway and are disposable to allow for the patient to maintain sterility. The project has adopted a user-in-the-loop approach to engineering design.
Aikenist Technologies Pvt Ltd
Aikenist Technologies is a Bengaluru based start-up that provides AI based solutions for faster scanning, better detection and quick turnaround time to make medical imaging accessible to larger population. The solution enhances patient convenience and improves return on investment for hospitals and diagnostic centres. They have developed a cloud-hosted AI solution called AIkenist QuickDiag COVID 19, which is compatible with all kinds of digital X-ray and CT scanning machines. The chest X-ray and CT-scan images are pushed to the cloud service where lung anomaly is diagnosed to screen COVID-19 patients. They also offer an AI-based product called Quickscan for MRI scans, for four-times faster diagnosis. Their other product, Quickdiag, provides AI-analysis for tumour detection and segmentation of brain, liver, pancreas, etc.
Cardiac Design Labs Pvt Ltd
Cardiac Design Labs is a Bengaluru based start-up providing efficient cardiac monitoring and diagnosis by deploying intelligent systems that enable automatic remote reporting that saves both time and cost. This is possible with their intelligent wearable device running on proprietary algorithms and a connected system for real time access and reporting. The Padma Vitals Telemetric Patient Monitoring System is a centralized vitals monitoring system with all vitals such as ECG, respiration rate, SpO2, body temperature and blood pressure being measured continuously for analysis and monitoring enabled through telemetry. This gives monitoring capabilities from a central location where multiple patients can be simultaneously monitored. This central location could be a nursing desk monitoring in a ward or a remote monitoring center/hospital. AI based algorithms will alert in case a patient needs attention. The company is a recipient of may wards like “Market Place of Medical Innovations” by ICMR, 2017, “Emerge 50 league of 10” for the year 2016 by NASSCOM and Winner of “Grand Jury Prize” at Startup India Launchpad 2016 by Google.
Biodesign Innovation Labs Pvt Ltd
Biodesign Innovation Labs is a medical device and healthcare technology start-up based in Bangalore, working on a lifesaving affordable and portable medical device ventilator. RespirAID is an easy to use, portable mechanical ventilation device that provides volume-controlled ventilation for patients in ER, Ambulance, Post-operative care, anaesthesia, transport ventilation and ICU. The product has helped save 50+ lives across hospitals in Karnataka. It has been deployed in 20 + major hospitals across India such as Manipal Hospital, Narayana Hospital, Yenepoya Hospital, St. John’s Medical College, Karnataka government hospitals. The company was featured in Forbes India cover page and in Forbes India's 7 Indian "Ventures Vs Virus”. The company is also a recipient of the Qualcomm Design Challenge Award.
Trans Vitals Pvt Ltd
Trans Vitals is a Pune based startup founded in 2020. Transvitals is a Healthcare AI company providing healthcare & wellness data and intelligence services securely across the spectrum of sensors and various health indicators which are and will be used across applications of preventive healthcare to remote patient monitoring across various medical conditions in homes and hospitals alike. LifePatch™ Wearable Patch is first of the many connected devices from Trans Vitals. The Patch is designed to capture and wirelessly transmit user's temperature and activity data in real-time to the mobile phone. Mobile phone further transmits the relevant raw data and alert data to the server. This LifePatch™ device is specially designed for quarantine centers, covid-19 patient monitoring, and monitoring of front-line workers, nursing homes to monitor elderly patients.
Website: https://transvitals.in/ and http://lifepatch.ai/
SiCureMi Health Technologies Pvt Ltd
SiCureMi is a New Delhi based Healthcare Technology startup which aims to develop an “Intelligent Self Care” product providing personalized care by Signature Cure Using Medical Intelligence (SiCureMi) leveraging the power of data science, machine learning coupled with IoT devices, to analyze, predict, and manage chronic ailments, helping people gain control over their lives. They are developing an innovative and novel approach for predicting the risk of CVD which is different from existing fundus scanning by using OCTA and AI that will provide ophthalmologists and clinicians a risk assessment tool that is easy to interpret and saves time in terms of consultation and identifying the risk.
Giftolexia Solutions Pvt Ltd
Giftolexia’s mission is to help children with Dyslexia and other Sp. Learning difficulties realize their true potential by leveraging state-of-the-art screening tool for early identification based on Gaze pattern analysis. With Machine Learning based predictive modelling, the team determines the level of risk in an attempt to provide the best solution for class wide screening as mandated by RPWD Act. Presently, screening in English and Marathi languages have been developed and over 2500 students have been screened.
Avyantara Health Technologies Pvt Ltd
Developing a digital health platform which uses machine learning algorithms for predictive risk scoring of neonatal sepsis. Aimed at providing a comprehensive diagnosis earlier than the blood reports or culture tests, the Neonatal Sepsis Risk Predictive Score can be generated within 5 mins and helps in providing an early assessment of the baby’s risk. It enables multiple assessments at early stages about the onset of risk of sepsis among babies at different intervals. PreSco aims to reduce the time delay in diagnosis in the existing methods by harnessing longitudinal medical records. Such an assessment is proactive and leads to a rational use of antibiotics and reduces neonatal mortality.
Heka Medical Pvt Ltd
Heka Medicals India Pvt Ltd is an ISO 13485 & ICMED 13485 Certified company that is already developed an indigenous non-invasive respiratory support system called HekaFlo® which is an “IoT enabled High Flow Nasal Oxygen Therapy Device (HFNO)” for treating hypoxemia in spontaneously breathing patients with warmed and humidified oxygen up to 60LPM to patients. The HFNO technique scores over conventional oxygen therapy as it can tolerate deficiencies of unheated and non-humidified oxygen. It can regulate the temperature and moisture levels to provide greater comfort to infected patients.
Presently working on a modified animal surgery table, the team aims to develop a compact, portable, multipurpose, versatile, innovative, mechanical, disinfectable, cost-effective, easy on maintenance device that can be used in preclinical research laboratory, for all kinds of demonstration purposes, for wildlife Telemetry.
Affigenix is a Bangalore-based company with a focus on precision diagnostic kit development for personalized medicines. Their current portfolio includes a trypsin clearance assay kit. In addition, Affigenix is becoming a preferred service partner to few biopharma companies and also earning the reputation for professionalism, performance, and productivity. They have also developed unique best-in-class critical reagents (22 #s) that are sensitive and specific to measure and monitor the safety and efficacy of products in preclinical, early and late stage clinical trials. They have commercialized >22 reagents and kits and have started generating revenue.
Aten Porus is a young start-up focused on nanotechnology based therapeutics for lysosomal storage disorders and other rare diseases. Niemann-Pick Type C Disorder is characterized by over-accumulation of cholesterol in lysosomes caused by mutations in either the NPC1 or NPC2 genes. Aten Biotherapeutics has developed the Degradable Cyclodextrin Polymer (DCP) platform of therapeutics that has shown to have therapeutic efficacy against Niemann Pick Type C disorder (NPC) in NPC patient derived fibroblast cells. Since the DCP platform is based on nanoparticles, they are expected to have superior pharmokinetic profiles hence lowering the dosage drastically and improving patient compliance. Aten Porus have also started a company in the US and have secured follow-on funding from various sources.
Bugworks is a resident incubatee that aims to discover novel biopharmaceutical assets for the treatment of antibiotic resistant bacterial infections. A spin-off from Cellworks Research, Bugworks uses a systems biology approach to discover novel treatment options for hospital acquired infections. Through their innovative approaches, they have developed a stealth strategy by which antibiotics can successfully by-pass efflux pumps, which are a key defense barrier present on the bacterial cell envelope. Their current leads target the WHO 2017 Critical, Serious and Concerning infection threats. They are progressing a first-in-class novel chemical entity (NCE) that exhibits potent killing of pan resistant superbugs and difficult to treat pathogens. They were the winners of the CARB-X program and have secured follow-on funding from them.
Eyestem is a resident C-CAMP incubatee using stem cell and gene editing technologies to create breakthrough therapies for degenerative diseases of the eye. Age-related macular degeneration (AMD) affects the RPE layer of the retina and ranks third among the global causes of visual impairment. Eyestem’s vision is to create scalable and affordable stem cell therapy for these degenerative eye diseases. They have successfully grown retinal pigment epithelium and photoreceptors – two layers of the retina which are key for vision.
Geniron Biolabs is a Bangalore-based company with addressing the unmet needs of Rabies, FMDV, Mastitis and other chronic infectious diseases of domestic animals. Their core proprietary technology includes a platform for DNA synthetic vaccines. Their candidate for Rabies vaccine cum Contraception based on this technology is in the proof-of-concept stage. These vaccines could potentially protect millions of dogs from rabies and control the over population. Their mission is to make rabies free India by 2025. Their Preclinical contract research services ranges from antibody production services to toxicity studies. They have raised follow-on funding from the SBIRI scheme and are generating revenue.
Genext Genomics Pvt Ltd
Genext Genomics Pvt Ltd is a Nagpur-based emerging life science research start-up and contract research organization. GNG is working towards the development of recombinant proteins and monoclonal antibodies against clinically relevant targets through the integration of bioinformatics, recombinant DNA technology, proteomics and immunology using novel high-throughput technologies. Their in-house research focus involves identifying and validating a drug target for tuberculosis; they aim to develop a mAb based drug for TB. They have started generating revenue and have licensed one of their bio-pesticide formulations to Dharti Agro Fertilizers.
InvivoD Solutions Pvt. Ltd.
InvivoD Solutions Pvt. Ltd. is a university start-up and an off-shoot of research carried out in the laboratory of the co-founder (Prof. Pradip Sinha, IIT Kanpur) and focused on providing a novel platform for anti-cancer drug screen in vivo. InvivoD exploits the genetically tractable model organism, Drosophila, for screening of drugs against cancer induced by specific cancer-linked mutations that are also conserved in human. Their technology platform allows us to screen drugs against epithelial carcinoma and paraneoplasia, a syndrome often seen in cancer patients.The company is now focused on translating these findings into a Drosophila-based model system for cancer drug screening.
Kinome Pharma is a Bangalore based venture focused on developing solutions for neurodegenerative disorders. Their BIG funded project involves development of novel neuroprotective agents for Parkinson's disease. The company’s proprietary small molecule inhibitor compounds are derived from natural products. Kinome Pharma has a portfolio of proprietary compounds selectively targeting cell death signaling molecules implicated in neuroinflammation and neurodegeneration.
Luxmatra is a Cochin-based start-up working on developing a novel radio-wave responsive, biodegradable nanoparticle platform for image-guided hyperthermia combined with immunotherapy for liver cancers. LuxMatra will focus on developing biodegradable nanoparticles that can trigger hyperthermic response within tumors upon exposure to low-power radio-waves. Thus, LuxMatra’s approach is to convert an immunologically ‘cold’ tumor into a ‘hot’ tumor and thereby mobilize immune system to better identify the stealth cancer cells and pose an anti-tumor immunity.
Nurture Earth is an Aurangabad-based company that aims to serve as an Industry-academia bridge bringing in interdisciplinary technology development and engineering projects for execution by the industry members and students/faculty in a collaborative manner. NE works with international and local organization as a contract and collaborative research partner. Their in-house research focus is on testing the feasibility of using nano-magnetic discs for ablation of Cancer cells in vitro. This project was conceived as an application of Nanotechnology in a non-surgical targeted cancer cell removal procedure. Nurture Earth has recently started generating revenue through its collaborative projects.
OCT therapies is a Mumbai-based company working on establishing a mesenchymal stem cell bank to treat burns and ulcers. Burns fatalities account for an estimated 1.63 lakhs annually in India. Wound infection, septicemia, wound contracture, scarring and ulcer leading to cancer are common complications. OCT Therapies proposes to use a cell based approach for wound healing in burns and chronic ulcers using allogenic Mesenchymal Stem Cells (WJ-MSCs). These cells can eventually be used for composite wound healing as an alternative to skin grafting. They are also developing stem cell based therapies for skin and hair regeneration. They recently launched their hair regeneration product.
Pentavalent Biosciences is a resident start up mainly focusing on the development of novel vaccine molecules against fatal human diseases. Pentavalent is developing a vaccine formulation, comprising of 5 major influenza strains including type A and type B, in replication-incompetent form, for intranasal administration in human population. The resultant vaccine strains will be replication-incompetent, yet mimick wild influenza virus strain in structure. Due to this structural mimicking, the vaccine formulation comprising of all 5 major strains will be evoking highly promising protective immune response in the host. The vaccine will target multiple populations in both seasonal and pandemic influenza. Pentavalent has secured follow-on funding from GOK to take their study forward.
Sekkei Bio is a young start-up incubated at C-CAMP. The company is working to develop a peptide editing platform to specifically deliver peptide drugs orally. Using in silico and in vitro assays, the objective will be to select novel analogues of known peptide drugs that are amenable to oral delivery, without impacting its function.
Snaayu Lifesciences is a resident incubatee working towards isolating and characterizing novel analgesics from cone snail venom. Cone snails are venomous mollusks with around 700 species. A number of pharmacologically active peptides have been isolated from venoms of different species of cone snails. The long term goal of Snaayu Life Sciences is to use cell-based assays to target human disease pathways, particularly the nervous system, with pharmacologically active venom components to generate drug leads.
Pandorum Technologies Pvt. Ltd.
Pandorum Technologies Pvt. Ltd. is a Bangalore-based company that develops proprietary science and technology platforms with the vision to manufacture personalized homo-chippiens and human organs on demand. They recently created artificial liver tissue by incorporating hepatocytes in biomaterial; this research has important implications in drug discovery. Pandorum’s artificial 3D liver tissue (organoid) efficiently recapitulates human liver tissue at the structural and functional level. They are resident incubatees at C-CAMP and have established POC and have received follow-on funding from the govt. and angel investors Flipkart founders Sachin and Binny Bansal.
Theramyt Novobiologics Pvt Ltd
Started in 2013 and based in Bangalore, Theramyt Novobiologics Pvt Ltd is a biotech company focused on biologics and biobetters. Theramyt’s strategic goals include a steady progression on the value chain towards biobetters and NBEs. Theramyt Novobiologics is developing two unique technology platforms for antibody engineering that are critically important to achieve next generation of monoclonal antibody therapeutics. They have already filed 6 provisional patents related to their product and platform development technologies. They have received follow-on funding from various venture capitalists, including ACCEL partners, AARIN Capital Partners, IDG ventures, and KITVEN.
Viravecs is a resident incubatee focusing on developing transgenic model systems for life science research. Currently, they are working on a novel technology to generate transgenic eukaryotic cell lines with no off-target effects. They use cutting edge genome editing tools, engineered viruses and nanoparticles to develop transgenic cells and mouse models of various diseases. Viravecs Labs also caters to the academia and the industry to develop stable transgenic cell lines using CRISPR-Cas9 based genome editing and viral vectors. Viravecs has secured follow-on funding from Ideas2POC and have started generating revenue.
Vital Bioscientific Solutions
Based out the Madras, Vital Bioscientific Solutions is a very recently established venture founded by a couple of IIT-Madras graduates. Their BIG funded project involves, development of a novel monolayer based parallel artificial membrane permeability assay to determine permeability of chemical entities and drugs. The monolayer coating is bio-mimetic and expected to be more efficient and cost effective as compared to gold standards used in the industry.
Western Range Biopharmaceuticals
Western Range Biopharmaceuticals is an Ahmedabad-based biotech start-up developing treatment modalities for cancer patients. They have built proprietary technologies for cancer cellular immunotherapies, personalized chemo-sensitivity tests, GvHD reduction and screening for HPV infection, one of the major causes for cancers in both men and women. The tests are based on a blood sample and will provide clinically relevant information. They have secured follow-on funding (SIBRI Grant from BIRAC, and are in the process of raising private funding.
Dr. Jonathan Pillai
Dr. Jonathan Pillai is an individual entrepreneur developing a novel implantable drug delivery system for sustained release of first-line TB drugs to improve patient compliance. To this end, they are designing a subcutaneous, surgically implantable, drug-delivery device that will eventually auto-deliver the standard 4-drug anti-TB regimen for the first 2 months, and INH and RIF for the remaining 4 months of treatment, equivalent to current oral drug protocols. By converting the problem of daily adherence to into a one-time surgical challenge easily addressed by the placement of an implantable drug delivery device, this innovation will drastically lower the threshold for adequate anti-tuberculosis therapy and treatment completion rates.
Dr. Karthik Venkateshan
Dr. Karthik Venkateshan is an individual entrepreneur working to develop printable biobased filament prototypes wherein the formulation and processing characteristics have been optimized for printing specifications. His project focusses on developing bio-friendly and low cost formulations that are developed from polysaccharides, plant proteins, biopolymers and other biomodifiers and biofillers (biomaterials) that can be used to produce 3D printable filaments. The applications of this technology include the 3D printing of biomedical products such as implants (ear, dental etc.), prosthetics and scaffolds.
Dr. Srujan Marepally
Dr. Srujan Marepally is a lipid chemist working in developing topical/transdermal therapeutics for chronic skin inflammations such as psoriasis, ACD and eczema. Srujan is working towards the development of safer, effective and economical therapeutics from a biological source, bile salt.
Dr. Vikas Mehra
Dr. Vikas Mehra is an individual BIG awardee. He is developing a diabody against TNF-alpha and IL17R for use as a therapeutic intervention for the treatment of psoriasis. Existing drugs/biologics for psoriasis focus either on TNF-alpha or IL-17, which have an established role in the disease. IL-17 synergizes with TNF-alpha to induce several inflammatory genes. the proposed scFv diabody will be novel in its approach, by combining two crucial validated disease targets in psoriasis. Blocking both these factors simultaneously might reverse the clinical symptoms of psoriasis.
Dr. Vinod Nayak
Dr. Vinod Nayak is an academician who aims to develop tools for high-throughput cloning and protein expression in S. cerevisiae. Particular emphasis is on developing plasmids for the expression of membrane proteins and multi-protein protein complexes. Their goal is to design and implement a flexible suite of shuttle vectors with multiple promoters and affinity tags to express genes in Saccharomyces cerevisiae. Since their method does not rely on restriction enzymes, it can be used in a high-throughput format.
Dr. Yashoda Ghanekar
Dr. Yashoda Ghanekar is an individual BIG awardee working on the establishment of invertebrate transgenic model systems through modification of lentiviral systems. Hydra and Planaria are two invertebrate model systems that have emerged in recent years for studies in stem cell biology and regeneration. They are currently developing gene delivery systems for Hydra and Planaria for generating transgenic lines. Such genetically tractable invertebrate model organisms would be an excellent system for performing preliminary screenings in drug discovery, environmental studies and toxicology in combination with the currently available model systems.
Plabeltech Pvt. Ltd.
India based Plabeltech is built on chemical technologies invented by Prof. Vishal Rai and his colleagues. The company delivers precision labeling of proteins and antibodies with the probe of interest. It offers excellent flexibility to the researchers regarding the site of conjugation and type of probe. The technological breakthrough also makes it possible to render ample quantity of analytically pure tagged proteins. Homogeneously immobilized proteins and antibodies are also delivered as per the requirement. Developed an in-house kit for multifold enhancement in the sensitivity of peptide detection (MS), peptide mapping (MS), and their fragments (MS-MS).
Fibroheal Woundcare Pvt. Ltd.
Fibroheal Woundcare Pvt Ltd is a startup working on various biomedical application of silk proteins for various healthcare needs. It work on Bio Modified silk proteins to develop various innovative and patented medical devices / products for Advanced and Active wound care management. Won a prestigious award from BIRAC for our innovation and commercialising a patented product from Silk Protein which assists in faster healing of wounds through higher scaffold formation and tissue regeneration.
Aman Aggarwal is a researcher cum entrepreneur from the renounced NCBS. His interests include the screening of neurodegenerative diseases using Drosophila. Presently, he is developing a novel, cost effective, rapid in-vivo drug screening platform for neurodegenerative diseases, such as PD, using Drosophila. Drosophila has many advantages, viz. low working cost, short life span of 2 months and strong genetic tools, over traditional model systems, along with having a BBB. Recently, drug discovery pipelines have also established Drosophila as an intermediary in-vivo system for drug screening. This proposed rapid and highly sensitive method of behavioral screening, hence, presents a unique opportunity for in-vivo screening large number of compounds at a reduced cost and higher throughput.
Bioroot Exploration India Pvt. Ltd.
Bioroot Exploration is a startup based at Trivandrum co-founded by Dr. Parvathy Prasad, in the field of biomedical research and environment protection to improve the quality of human life. Expanding to manufacturing of medicines, chemicals, engineering and other consumable products that improve the quality of day to day life. Under this grant, the team is developing new, efficient non-toxic indigenous intravenous nanoparticle lipid emulsion as contrast agent for imaging lesions. This formulation consists of nanolipid emulsion exclusively using coconut oil, a medium chain triglyceride along with lecithin, sodium oleate, glycerol and later incorporated with iodine in the safest form - 2, 3, 5 triiodobenzoic acid and vitamin E. This oily medium works as an effective drug carrier, and tumour-seeking embolic agent, all at once. Most importantly, it is iodinated and can thus be easily visualised using any X-ray based imaging modality such as fluoroscopy or CT.
Dr. Deepthy Aravindakshapillai
Dr. Deepthy Aravindakshapillai, a material scientist and an entrepreneur, focused on leveraging the potential of nanotechnology-based innovations in developing clinically translatable biomedical devices. Particularly, the emphasis is on developing localized nanodrug delivery systems for therapeutic applications in the clinics. The BIG project utilises an innovative nanotextile-based technology for developing drug eluting self-expanding metallic biliary stents. Nanofibrous textiles laden with the standard-of-care chemodrug Gemcitabine, when integrated with the stents would provide localized and sustained drug delivery for several months. This would help to mitigate biliary obstruction and maintain stent patency for prolonged durations, which is currently an unmet clinical need.
Seragen Biotherapeutics India Pvt. Ltd.
Seragen is a Biotherapeutics company based at Bengaluru co-founded by Mrs. Vasanthi Palanivel, that helps IVF specialists, Ob-Gyns and Andrologists succeed treating infertility conditions. Seragen solutions treat humans, cattle and agriculture, Artificial Reproduction space, magnifying intervention outcomes helping overcome infertility conditions. SeraGel, is a patented novel medium for storage of semen and pollen at ambient temperatures such that the original quality of semen and pollen is retained. Leading Agri companies like Rasi Seeds have experienced remarkable germination/ pollination using Seragel. Seragel is easy and convenient to use for Semen storage and shipment and ensures high stability without losing potency, Reduced ROS rate, and Reduced DNA damage vis-à-vis conventional cryostorage.
Dr. A. Michael
Dr. A. Michael is an academician cum entrepreneur having about 28 yrs of teaching experience in the field of applied sciences of Biotechnology at PSG College of Arts and Science, Coimbatore. He has been working on Chicken egg yolk antibodies since 1998 and has generated antibodies in chicken against various bacterial, viral, fungal infectious agents and against Indian Poisonous Snake Venoms. Currently, developing a highly purified, cost effective Chicken Egg Yolk IgY antibody that enables improvement in Food nutrition and Healthcare in Humans and Animals under the BIG grant.
Hanugen Therapeutics Pvt. Ltd.
Hanugen Therapeutics was established to provide high quality oligonucleotides. Hanugen Therapeutics is committed in developing improved methods of oligonucleotide synthesis and for the design of superior modified oligos. Their novel chemistries allow them to address specific genetic diseases by altering the RNA transcription process and thereby modifying protein structure. They specialize in modified oligos, fluorescent probes, long oligos and large scale oligo synthesis. The more modifications that are present in an oligo, and the longer the sequence, the more demanding the synthesis and purification. They are committed to the rare disease community beyond the development of meaningful therapies by delivering advances in oligonucleotide based medicines.
Total Potential cells Pvt Ltd
Total Potential Cells Pvt Ltd. (TPC) is a research dedicated company incorporated in 2011. It is recognized as such by Department of Science and Industrial Research, Government of India. USP includes taking the research from bench to bedside is – Mesenchymal stem cell. MSC is progressed to translation into all three germinal layers and research is published as Indian Innovations by Indian Journal of Plastic Surgery.
Biotide Solutions LLP
Mr. Nitin Yadav, Founder is developing conformationally restricted short peptides as drugs and drug delivery vehicles for cancer. In the current project, he proposes to develop cationic helical peptides as antimicrobial agents against multidrug-resistant bacteria to combat the emergence and dissemination of antibiotic-resistant microorganisms. Because of the unique multi-targeted mechanism of action of cationic helical peptides, they represent a class of antimicrobials which can act against the drug-resistant bacterial strains, and because of this fact, it may not be easy to develop resistance against this class of compounds. New template peptides, containing conformationally restricting residues in their sequence, α,β-dehydrophenylalanine, will provide longer half-lives and represent a novel class of compounds for therapeutic purposes. Easy synthesis, characterization, and high biocompatibility will also make this novel class of antimicrobials very attractive leads for further development.
IonCure Tech Pvt Ltd
Ioncure Tech is a healthcare and pharmaceutical company based at Delhi uses the best of Artificial Intelligence, Data Science and Multi-Disciplinary Drug Discovery Approaches to deliver healthcare and wellness solutions on the premise of affordability and accessibility to all. They offer pioneering solutions for SARS-CoV2 and epilepsy. At present, they are developing select brain-permeable peptides and small molecules, targeting BK channels, as anti-epilepsy drugs. This approach will have fewer side effects, lasting effects on the clinical symptoms and much more cost effective which therefore can be available to a number of patients.
Dr Abrar Rizvi
Abrar Rizvi completed his PhD from FIRC Institute of Molecular Oncology, Milan and later joined Jamora Lab at InStem, Bangalore as a post-doctoral fellow. Abrar is a researcher and an entrepreneur with expertise in Molecular Cell Biology. At present, he is developing a high-throughput screening technology to identify molecular inhibitors of fibroblast activation. Using this technology, he intends to discover molecules that specifically target the epicentre of fibroblast activation pathways, involved in the development of tissue fibrosis. He further intends to validate the lead compounds in vivo in fibrotic mouse models and to develop safe and effective drugs for the treatment of various fibrotic diseases.
VriVida Private Limited
Vrivida's first flagship product is a recombinant protein that will be developed as a medicine for slow healing-wounds including diabetic wound and peripheral ischemic wound. The recombinant protein is inherently stable at ambient temperature, and this will facilitate its production, storage and in its therapeutic application, which are all major limitations in utilising protein-based wound healing therapeutics. Our final wound care product will be a topical medicine and will target customers who are looking for novel, effective, easy-to-use and cost-effective solution.
Dr Tanay Bhatt
Since the global issue of AMR requires multipronged approach, Tanay and team are focusing on host directed therapies, particularly endogenous antimicrobial peptides (AMPs). Unlike antibiotics, which have single targets on the bacterial cell structure or metabolism, AMPs are capable of clearing infections in numerous ways and are also involved in pathogen clearance via immunomodulation. Though the skin cells are known to contain huge pools of AMPs, the mechanism regulating their secretion remains unknown and is an obstacle towards using this resource as a therapeutic tool to counteract microbial infections. The team is presently working on a siRNA based topical formulation, which can trigger the release of body's own AMPs for protection against microbial infection. This new technology, controlling AMPs release on-demand, would provide a formidable new line of defense against the growing list of pathogens that are resistant to antibiotics.
Atlantis Science India Pvt. Ltd.
Alantis Sciences India Pvt. Ltd., discovers and develops biotechnological solutions for diagnosis and treatment of human diseases by deploying directed evolution of molecules with safe and better functionalities. Directed evolution banks on the principles of natural selection and methodologies have proved effective in both improving desirable qualities of proteins and in the detection of relevant structural sites. This process consists of two major steps - generation of libraries based on the original gene after random or directed mutagenesis, and selection of variants based on desirable attributes. Team @ Alantis has chosen to address the problem of coagulopathies - a significant problem in blood coagulation pathways and these disorders affect about 1 in 10,000/15,000 individuals. A swift and rapid acting protein will have significant medical applications in both inherited and sporadic bleeding conditions.
4baseCare Genomics Pvt. Ltd.
4baseCare is a precision oncology company and has a vision to make personalised cancer care accessible and affordable for cancer patients in Asia. The team is currently working on developing a novel precision oncology platform which identifies true response biomarkers by integrating drug response in patient-derived organoids, tumor microbiome profile, and molecular characteristics of the tumor along with whole-exome and transcriptome analyses. This platform would offer a unique opportunity to stratify cancer patients based on the tumor and host molecular profile that helps oncologists to take accurate decisions on individual patients more effectively.
Swalava Enterprises Pvt. Ltd.
The team is working on Hot Melt Extrusion (HME) Technology which is a solvent free, continuous, and cleaner process will be used for enhancing drug solubility by Amorphous Solid dispersion and Solubility Enhancement of BCS class II and Class IV drugs. An antihelminthic product is aimed to be developed using HME to overcome low bioavailability, animal handling challenges during dosing with improved efficacy and compliance.
AAARNA Therapeutics is focused on developing therapeutics and vaccines for infectious and non-infectious diseases to contribute to a healthy India by means of self-reliance in the area of mRNA therapeutics. The Knock Out of Infectious Viral Diseases (KOVID TM) platform is targeted for mRNA based therapeutics against respiratory viral infections to strive and design cost effective, stable mRNA therapeutics which do not need special refrigerated storage and transportation.
Cisgen Biotech is a Chennai-based company working on developing a POC diagnostic kit for bovine TB. Bovine tuberculosis (BTB) is one of the major animal health issues in developing countries and it is an under-estimated cause of zoonotic human tuberculosis (TB). Sero-diagnostics constitute an attractive option for bovine TB diagnosis as they are simple, cheap and non-invasive. Cisgen is developing a rapid immuno chromatographic test for TB antibody detection with the following novel characters.
Giga Builders Pvt. Ltd.
Giga Builders Pvt. Ltd. is an agri-based start-up studying plant growth & response under precisely maintained soil moisture status at desired level. They aim to develop a minilysimeter device for precise imposition of soil moisture stress. This unique device can precisely quantify the stress response of diverse crops / genotypes. They are in the process of further testing their first prototype. The device has a phenomenal relevance and significance in identifying the crop varieties with improved draught tolerance and productivity.
Sea6energy is a young bio-energy company developing end-to-end solution to replace the fossil fuels. Sea6 Energy is guiding its efforts towards low-cost, large scale cultivation of red seaweed on the ocean and developing salt water-based biotechnological processes to produce biofuels, agricultural biostimulants and phycocolloids from red seaweed. Their first product, AGROGAIN™, is a plant growth stimulant from seaweed extract that is now in the market through their partnership with Mahindra & Mahindra. They have raised private investment from Tata capital and they continue to incubate at C-CAMP, where they have expanded from their 6-member team to around 30 scientists and non-scientific staff.
SM Plant Technologies
SM Plant Technologies is a Bangalore-based company that proposes to micro propagate quality planting materials of economically important plants in bioreactors, which provide superior mass balance, higher proliferation rate, improved labour efficiency and as a consequence, reduced cost compared with conventional techniques. They have developed processes for commercial scale-up of conventional micro-propagation of banana in suspension cultures using bio-reactors. They have commercialized their banana planting material, and have recently started generating revenue. They have secured follow-on funding from the National Horticultural Mission.
Dr. Mahesh H. B.
Dr. Mahesh H. B. is an individual entrepreneur who is interested in isolating secondary metabolites from Bacillus sp. With antimicrobial activity against plant pathogens. Bacillus has been reported to have high biocontrol activity. He aims at commercializing the potential Bacillus strains and characterize the active biocontrol molecule that is stable with respect to its efficacy, production and storage.
Dr. Mohan Subramanian
Dr. Mohan Subramanian is an individual scientist incubating at Translational Research Platform for Veterinary Biologicals, TANUVAS. His BIG-funded project involves development of a novel therapeutic biosimilar for canine parvoviral enteritis. The therapeutic is a recombinant fusion protein that targets the viral receptor and neutralises the virus.
Equine Biotech Pvt Ltd
Equine Biotech is a start-up based at IISc. They are developing point of care diagnostics, including a lateral flow and a PCR chip for field based detection of animal Trypanosomasis (Surra)
Fibsol Life Technologies Pvt Ltd
FIB-SOL aims to translate advanced material technologies from research to industry. They design nanofiber platforms to create light-weight delivery formulations for agri-inputs such bio-fertilizers, pesticides and other plant growth stimulants.
Thomas Biotech & Cytobacts Centre for Biosciences (OPC) Pvt Ltd
Pious Thomas currently the CEO & Director of "Thomas Biotech & Cytobacts Centre for Biosciences", a biotechnology company at Bengaluru, India. The company deals with research in the emerging area of biotechnology with special reference to Endophytic Microbiology. Developmental front, the major interest is micropropagation of elite papaya. Previously Dr. Thomas was affiliated with the Department of Biotechnology, Indian Institute of Horticultural Research as Principal Scientist and Head i/c. Pious does research in Agricultural Plant Science, Horticulture, Plant Protection. Biotechnology and Endophytic & Molecular Microbiology. Their current projects include Plant tissue cultures/ micropropagation & Endophytic Microbiology through metagenomics.
Dr Gowsiya Shaik
Dr. Gowsiya Shaik is an entrepreneur working towards adapting aeroponic technology for the cultivation of plants with medicinally useful components in their roots. Aeroponic cultivation is a soil-less cultivation of plants where roots grow in air in aeroponic chamber and a constant mist provides nutrients and water for growth. Such a precise plant growing condition will overcome several technological gaps like, options to substantially improve the root growth, option for multiple harvests, to avoid any rhizospheric contaminants and finally, an option to provide required environmental factors to enhance the root growth and metabolite production.
FarmGulp Pvt Ltd
Farm Gulp, Bengaluru based startup co-founded by Mr. Ganesh Bhat working in the sector of industrial biotechnology, secondary agriculture and Nutra Phyto biotechnology and aimed in the value addition of agricultural byproducts and the extraction of natural molecules applicable in a wide range of industries such as food & beverage, cosmetic & skin care, Health care & nutraceuticals, Home appliances etc. using Bioprocess techniques. Currently, working on the isolation of bioactives viz., EGCG antioxidants and Arecoline etc. from Arecanut Wash Liquid, which is the Karnataka’s largest available raw material for the production of Active Pharmaceutical and Nutraceutical Ingredients which are applicable in major industries using novel chromatographic and membrane separation process to achieve about 95% purity.
Daskdan Innovations Pvt Ltd
Daskdan Innovations is a startup based out of Kashmir focused on using artificial intelligence for purposing and/or repurposing Himalayan herbs for desired animal therapeutics with the main motive of working towards HERBAL RENAISSANCE and utilize it to deliver next generation herbal therapeutic solutions for animal industry. They are the pioneers in using the phyto biome of Himalaya for animal health enabling farmers to replace the medical grade drugs in animal feed with plant-based alternatives. Presently, they are developing animal centric Himalayan phyto-pharmacopeia, which is being explored as an option to replace the use of in-feed drugs, a first of its kind of double method approach for controlling Coccidiosis, the world’s costliest parasitic disease, caused by a protozoa named Eimeria.
Jeshron Biotech Solutions Pvt Ltd
Jeshron Biotech Solutions is a Chennai based startup working on veterinary medications to benefit animal health. They are developing a novel low cost biodegradable progesterone sponge for controlled release to induce oestrus for cattle breeding. The technology is user friendly and increases conception rate in cattle. The team also aims to evaluate the efficacy of biodegradable sponges loaded with different concentrations of progesterone for the induction of oestrus within 7 days and subsequent conception rate in cattle to facilitate easy breeding. This technology efficient and can be performed without the help of veterinarians.
Qzense Labs Pvt Ltd
Qzense Labs is a Bengaluru based startup transforming fresh food supply chain with Data, by offering an end-to-end IoT solution for fresh produce management. They are developing a hand held IoT device for detecting key features of internal quality of food. The solution employs a unique blend of spectral and olfactory sensors to capture the volatile information of fruits and proprietary machine learning models to give an accurate assessment of ripeness, spoilage, and shelf life. It assists in bringing down inventory losses and capturing optimal margins from the same produce. This technique can also help in detecting pesticide residues, bacterial infection etc. At present, they have selected five commodities to begin with: Apples, bananas, pomegranates, pears and kiwi.
Agrimaa Biosciences Pvt Ltd
Agrimaa Biosciences is a Srirangapatna, Karnataka based startup developed a varied range of F1 Papaya Seeds, F1 Jalapeno Seeds, F1 Marigold seeds suitable for different agro-climatic conditions / zones in the country. They are developing a corn seedling-based protein production platform for lowering production cost of industrial proteins. In addition, they are working on low-cost tissue culture, low-cost hydroponics and low-cost greenhouse technologies. They have developed a novel Agrobacterium mediated transient expression method, using which recombinant proteins can be expressed in all the tissues, including roots, of intact monocot seedlings like corn, rice, wheat, ragi etc. These monocot seedlings can be raised hydroponically with a possibility of massive biomass production in a small area of up to 7 million Kgs / Ha / year. Further, aim to boost recombinant protein production level in corn / rice through employing viral genetic elements viz., the replicase and the movement proteins.
Wide Mobility Mechatronics Pvt Ltd
Wide Mobility Mechatronics is a Hubli, Karnataka based startup leading the development, supply and integration of end-to-end machine vision & inspection solutions targeting various industries like food, manufacturing, health care, security etc. They are developing an X-Ray based fully automated inspection machine called CONRAD-G. It operates at an accuracy of over 95 percent in identifying infested gherkins and can handle up to 100Kg/h. The entire operation of Feeding-Inspection-Rejection is automated. Feeder consists of a hopper, 6 corrugated channels on which the gherkins vibrate and move to the conveyor belt. Inspection Unit consists of X-Ray unit, camera and in-house developed algorithms which image the gherkin and classify the gherkin as good/bad. The Rejection unit is pneumatic based, which blows out the bad ones into the bad bin and the good ones are collected in the good bin.
Faunatech Solutions Pvt Ltd
Faunatech Solutions is a Bengaluru based startup incubated at C-CAMP Bangalore, India. Faunatech was established with a mission to improve the productivity of dairy farmers globally by protecting the health of farm animals using novel diagnostic technologies. Currently, they are in the early commercial stage with four full-time employees. Their first product is a handheld somatic cell count system to detect mastitis in milch cows and buffaloes within 5 min. the technology can detect various stages of mastitis and is ready for pilot deployment. It is an end-to-end solution that helps cooperative managers or farmers to test, analyze and triage for care. The company has so far been funded through private capital from the founders and had raised investment through C-CAMP Beyond Next Ventures Innovation Hub (CBIH) to pursue early market pilots and scale-up of manufacturing.
Dendrite Laboratories Pvt Ltd
Dendrite laboratories works for a specialized product development and innovation for diagnostics of plant diseases by using LAMP assay based molecular on-site detection kits which are fast, specific, user-friendly and cost-effective to aid crop protection. Primarily targeting tomatoes, the team is looking to scale-up to other pathogens associated with cash and economical crops.
Engaged in development of pest management strategies that are based on similar chemicals Kairomones by studying the chemical clues that are used by pests for selection of host plants, to locate food and mating for non-invasive control of those pests. The technologies developed are strategically aimed towards reducing the population of the pests and rather than controlling after pest emergence.
Adis technologies works on use of AI ML on Animal Biometrics to unique identity to all animals with muzzle. At present there is no proper reliable database available in India. Cows on Cloud includes Cattle Management Tool Animal bio-metrics Big Data analytics & Using Artificial Intelligence & Machine Learning for cow recognition by implementing image processing algorithm i.e. CNN. The team is developing digital records of animals like health records, pedigree records, ownership records, insurance records and many others for the whole life cycle from birth to tomb. Leveraging smartphones to generate Big data for animals, on cloud with animal biometrics and facial recognition features on Centralized Database. ADIS is a android app used as a tool for capturing real time data of the animals which have muzzle. Algorithms are developed wherever the database throws up relevant info of entire chain, from inputs AI/breeding, vaccination, feed & fodder, milk production & nutrition to output Cow based products & animal impact.
Agdhi Technologies Pvt Ltd is on a mission to combine digital technology and human creativity to create sustainable methods in agriculture. Seedvision(SV) is a suite of products and technologies that will revolutionize the way global agriculture ecosystem process and handle Seed. Our solutions addresses wide range of use-cases like Traceability, Trackability, Quality Analysis & Measurement. We digitize physical seed and brings predictability & forecasting.
Dr. Darakshan Majid
Dr Majid and team are presently working on different herbs like Rheum emodi and Utrica diaocia native to Jammu and Kashmir. The bioactive components would be evaluated and translated into bakery products to overcome the problems faced by people due to diabetes.
FemtoFarad Pvt. Ltd.
FemtoFarad designs, engineers and cultivates non-GMO microalgae for flavourants, nutraceuticals and feed. The products are derived from their unique IP for non-GMO heme-protein production and purification through food-grade chemicals and processes. Heme- protein, which is responsible for meat-like taste, is intended to be used in FemtoFarad shellfish products (PeaShrimp) and sold as flavourant to other companies in faux meat industry.
A composite of two technologies to the small holding farmers has been targeted viz., an affordable Greenhouse coupled to a low-cost Hydroponic system. The affordable greenhouse hydroponic system does not need fan and pads for cooling the heat buildup and the hydoponic system does not need electricity.
Aspartika Biotech is a Bangalore-based company working on the development of value added products such as nutraceuticals, poultry feed, and aqua feed from the wastes/byproducts of palm oil mills and silk reeling industries. The major focus of the company is the development of omega-3 fatty acids for human and animal use. They also manufacture feed supplements for cattle, aqua and poultry. They have commercialized several of their products and have started generating revenue. They have secured follow-on funding from the Govt. of Karnataka, Idea2POC grant.
Mallipatra Nutraceuticals is a young startup working on the artificial cultivation of one of the most expensive mushroom, Cordyceps, which is highly valued for its medicinal properties. They intend to develop Cordyceps Health Products such as powders or capsules targeting both Business to Business (B2B) as well as Business to Consumer (B2C). Their technology mainly deals with the artificial cultivation of Cordyceps under controlled condition mimicking its natural condition and further processing by harvesting, analysis, drying and packaging for business to business market. They have commercialized their cordyceps-based nutraceutical and have raised follow-on funding from several sources.
Robust Herbals is a Bangalore based start-up with a focus on developing Ayurveda’s herbal tradition into a range of proprietary technologies and formulations as alternatives for existing pharmaceuticals/drugs. In addition, they are developing a biodegradable biocompatible blood pool contrast agent based on a rod-like nanoparticle constructed from FDA approved materials with superior contrast enhancement.
Theevanam Additives & Nutraceuts Pvt. Ltd.
Theevanam Additives & Nutraceuts Pvt. Ltd. is a Start-up company at IIT Madras Research Park - IITM Bioincubator, with a commitment for excellence in bringing quality products and technology in food and feed additives sector. They are working on the development of the novel formulation of natural polysaccharide immunity booster for booming Shrimp aqua industry of India. The formulations are aimed for efficient absorption and higher potency by controlling the particle size and preventing the aggregation in the biological fluids. The introduced formulation is going to be standardized for dosage amount and frequency through statically designed lab trials as well as field trials. The formulation is expected to efficiently eliminate major infections and stress/morbidity usually encountered in shrimp cultivation at hatcheries as well as open ponds/farms and thereby the formulation will improve the overall productivity.
Prof Ram Rajasekharan
Prof. Ram Rajasekharan is an academician with 30-years of experience is now practicing the biochemical principles as an enterprise. Human sucrase enzyme is a key therapeutic target for type 2 diabetes as it has efficient way to control hyperglycaemic conditions. While plant sucrase (invertase) inhibitor modulates the invertase activity thereby accumulates sucrose during plant development. Molecular level understanding of sugarcane invertase inhibitor towards mammalian α-glucosidases was established by his team. A synthetic peptide of 28 amino acids of middle region of the inhibitor has a dose-dependent binding with sucrase. Naturally derived carbohydrate mimics are promising at in vitro conditions and a new horizon towards peptides derived from food are emerging out of this project.
Biomoneta is a resident C-CAMP incubatee. They are currently working on the design of a novel air purification device for the reduction of airborne bacteria. One of the ways healthcare associated infections are spread in ICUs is via aerial transmission. Biomoneta is working on an air purification device that specifically reduces air borne bacterial contamination in ICUs and sick rooms. The device exploits the electrical properties of bacteria, novel antimicrobial fabrics and engineering design; and is meant to be a bedside unit that both prevents an infectious patient from spreading the disease and protects a naïve patient from acquiring an infection. They have secured follow-on funding from angel investors, SBIRI and Idea2POC schemes.
Butacel Bioresearch is a young start-up incubated at Technology Business Incubator (TBI), University of Delhi. They are developing processes for microbial overproduction of 2,3-butanediol from lignocellulosic biomass based on metabolic engineering. Rising concern over the cost and sustained availability of the fossil fuels, and its impact on the global warming, motivated them to find alternate fuel resources, preferably renewable resources. The proposed process will not only fulfill the huge energy demand in our country, but will also help in alleviating dependency on foreign oil reserves.
Cleanergis is a resident incubatee developing innovative, high-quality enzymes for food and waste-water-treatment. Cleanergis has developed microbiological methods for decolorization and detoxification of molasses spent wash (MSW). Also, they have demonstrated that algae can grow on treated MSW. Their product, "MatClean" is an enzyme consortium to clean Mollases spent-wash. The product is provided as a matrix. The product is used to service Sugar-cane Industries for Bioremediation. The major outcome of the implementation of these technologies is to get clean, odorless and safe water that can be used for agriculture or which can be disposed-off to the river/stream. Their project selected in top 50 innovations in India Innovation Growth Programme 2015.
Codon Biosciences Pvt Ltd
Codon Biosciences Pvt Ltd is a start-up based in Goa. Their main focus is the development and production of fruit based value added products. Their first product, “Pomar De Frutas” mango wine is produced exclusively from Alphonso mangoes by using a patented wine-making recipe that involves enzymatic maceration of mango pulp. The wine is golden in color, crisp with a fruity aroma and a long lasting finish. Codon Biosciences has raised follow-on funding from the SBIRI grant by BIRAC, Govt. of India.
India Biolabs is a young start-up dedicated to researching novel all-natural antimicrobials for the food and pharma industry. They are isolating novel Lactic Acid Bacteria, from food spoilage microflora with antimicrobial activity to improve food safety and shelf-life against fatal foodborne pathogens such as Salmonella spp., E. coli spp., Listeria monocytogenes, Clostridium spp., Bacillus subtilis and Staphylococcus aureus. In the future, they plan to conduct cutting-edge research on bioactive phytochemicals, probiotics for the food and animal feed industry as well as development and validation of antimicrobials/antibiotics.
openwater.in is founded by Dr. Sanjiv Sambandan and is a spinoff from the Flexible Electronics Lab, Department of Instrumentation and Applied Physics, Indian Institute of Science, Bangalore. The main goal of this startup is to provide smart solutions in the area of waste water management. Openwater has devised a technology that generates potable water from wastewater without the use of membranes or synthesized chemicals. It relies on the use of spatially and temporally patterned electric fields to improve throughput with no water wastage and make the process very energy efficient. The technology can be revolutionary in remote locations where there is very limited access to clean water. It will be highly efficient for those stuck in disaster hit areas. Openwater has demonstrated POC and is working towards the commecialization of their technology.
Shirdi Sai Nutraceuticals
Shirdi Sai Nutraceuticals is a Bangalore-based company working on the development of high performance immobilized lipases for non-aqueous esterification of oils and fats in stirred batch reactors. They have also filed an Indian patent application for improved enzyme degumming of vegetable oils. There are several ways in which one can enhance the performance of enzymes, and lipases in particular, for both aqueous as well as non-aqueous processes. This company intends to make use of the recent advances in this field in an innovative way and come up with simple and low cost processes for making healthy modified fats. They have started generating revenue and were recently approved for follow-on funding from the BIPP scheme of BIRAC.
A Bangalore-based company, String works at the interface of biology, chemistry and engineering. They leverage their platform – SIMP (String integrated methane platform – to deliver methane from wastes and natural resources using engineered micro-organisms. The startup converts methane, a waste gas responsible for much of livestock production’s greenhouse gas emissions, into proteins that can be used in animal feed. They have secured follow-on funding from several sources, including SIBRI, SPARSH and ELEVATE100 grants.
Log 9 Materials
Log 9 Materials is a nanotechnology company with a determined team of scientists and engineers working on commercializing graphene. The development of new frontiers in graphene synthesis of various forms, reduction and functionalization and designing innovative applications paved the way of the foundation of the company. It is one of the fastest growing innovative R& D start-ups which was awarded ISBA – 2017, the best start-up award in last year.
Harvestwild Organic Solutions Pvt. Ltd.
HarvestWild Organic Solutions manufactures bio-surfactants from unutilized soapnuts harvested by tribal communities, thus providing them with livelihood. These bio-surfactants are used in formulating natural and ecofriendly cleaning products. The enterprise is looking to benchmark the performance of bio-surfactant Saponin available in soapnuts with industrial surfactants. It is also looking to further optimize the extraction conditions for improving the yield of saponins from soapnuts so that lower cost of extraction along with optimum yield paves way for its industrial adoption. A major problem with crude saponin extracts is its high cost of purification. The enterprise is looking to create extremely efficient and low cost methods of purification and isolation.
Drumlins Water Technologies Pvt. Ltd..
Co-founded by Dr. Suphiya Khan who is presently an Associate Professor, Department of Bioscience and Biotechnology at Banasthali Vidyapith. Dr. Suphiya Khan’s path breaking research work on Fluoride removal from drinking water titled “Defluoridation technology for drinking water and tea by green synthesized Fe3O4/Al2O3 nanoparticles coated polyurethane foams for rural communities” was featured in the highly respected Nature Journal. She is also emerging as bio entrepreneur with her startup venture Flo Aqua Remedies & Company Ltd founded by her for commercializing this technology.
Tranalab is developing novel methods for BioSimilars production. Systems with broad platform potential are being examined, with a focus on IP opportunities. Initial propositions are on 'High Value - Low Volume' proteins with potential extension to produce bulk volume proteins at a subsequent stage of technology maturation. Both therapeutic (to treat human disease conditions) and non-therapeutic proteins (Lab/R&D/Analytical/Diagnostic use proteins) are under purview.
Prakhoj Pvt. Ltd.
Prakhoj Pvt Ltd is a Bengaluru based startup co-founded by Dr. Anirban Pal working on malodour management and long lasting freshness by a novel technology for Health and Hygiene. The product named Malodorex Activ SLR (MXA-SLR) which is a liquid concentrate of nano-complexes of chitosan and fragrance molecules and non-pathogenic bacterial consortium adept in malodor management. The approximate bacterial cell count of the product is >300 million CFU/ml. The preliminary data from Indian Railways, brewery pubs, clubs and hostels in Bangalore and reports available are very encouraging. The preliminary studies have been extended to evaluate our technology with competitor products by a NABL laboratory. It was observed that MXA-SLR was effective for 18-20 hours vis-à-vis 2-5 hours of competitor brands in a single application and also saved 100 L of water at the same time.
VT Ecogreen Technologies Pvt. Ltd.
VT Ecogreen Technologies, a Coimbatore based startup co-founded by Dr. Lipin Dev, developing eco-friendly technologies for application in the field of food, agriculture, health and environment. Our first product with the brand name “CRONUS” which is available in the market is a chemical free white pepper produced from dry black pepper using microbial fermentation method. The byproducts from this process such as nutrient rich water and biomanure have great commercial value. Hence, the process turns out to be most hygienic method for white pepper production with zero waste. At present, Ecogreen is working on an improvised technology for the production of white pepper by optimization, design and development of a novel enzymatic technology to replace the existing microbial fermentation method to overcome the limitations in the process parameters.
Zero Plast Labs Pvt. Ltd.
Aditya Kabra is an entrepreneur with 6 yrs of research experience in various domains of basic sciences. He is the Founder and CEO of ZeroPlast Labs, a R&D startup with an aim to solve India's plastic pollution problem. Developing single-use, cost-effective, hygienic food packaging products (cups, plates and straw) with bacterial nanocellulose or cellulose nanofibers based coatings that will be compostable in soil as per ISO 17556 designed for meeting the quality and performance standards. Nanocellulose coated paper products are only cost-effective, hygienic, food-safe and quality products in the market which will be soil compostable as per ISO 17556. Our first product would be 100% soil compostable (ISO 17556) coffee cup.
Kcat Enzymatic Pvt Ltd
Kcat Enzymatic, a Bengaluru based startup is an enzyme/protein engineering group that specializes in providing optimized enzymes for industrial applications. They are a bunch of computational chemists and biologists with expertise in deriving transition and intermediate states of bio-catalytic reactions using molecular dynamics and quantum mechanics simulations. The proprietary technology, 7th Dimensional Grid technology employs quantum beads to capture the accurate electronic details across an Enzyme-Substrate reaction and across the Enzyme-Substrate system. By capturing these transient events of a reaction, at the atomic and electronic level, they implement their internally developed algorithms to examine and derive focused libraries of enzymes with desired properties. Subsequently, laboratory validations are carried out by performing experiments such as mutagenesis, protein purification and biochemical studies to determine enzyme activity and kinetic resolution. At present, they are working to engineer Transaminase with high Kcat values 800 folds increased activity and stability for industrial production of antidiabetic Sitagliptin, antiepileptic Pregabalin and a specific herbicide.
Foundation for Neglected Disease Research (FNDR)
Foundation for Neglected Disease Research (FNDR) is a not for profit company dedicated to delivering novel cost-effective treatments and diagnostics for neglected diseases which are of interest to India. FNDR is developing a product which is an in-line device implemented at points of entry of untreated wastewater into the environment. The device has a cartridge of materials (novel adsorbent mix from plant waste material with a high adsorbent capacity) which adsorbs antibiotics from the wastewater with a specific adsorption capacity 125-250 mg of antibiotic load/gm of adsorbent. The preliminary assessment has suggested upto 10000L of water can be cleared of several antibiotics including fluoroquinolones with 1 Kg of such adsorbent mixture. The adsorbent mixes have been formulated to adsorb diverse antibiotic classes which have a major role in development of AMR.
Biotherm Flavours & Fragrances LLP
Biotherm Flavours and Fragrances LLP core activity is on developing technological solutions related to extraction and improvement of secondary metabolites. The traditional practices in fragrance industry are age old and becoming economically unviable due to escalating cost. This has led to adulteration and use of synthetic alternatives. They are working on solutions which can improve the secondary metabolite production by biotechnological interventions at each and every level. Their work also comprises of genotype improvement programs, molecular and hormonal interventions to improve secondary metabolite production by adopting alternative and novel extraction methodologies. Currently, they are focusing on the issues faced by fragrance and flavor industry and are working to enhance the yield of vetiver oil upto 3-4 folds higher.
Ajaya P Katti
Mr. Ajaya Katti is a researcher turned entrepreneur having vast research experience in upstream processing of microalgae as a post graduate in Industrial biotechnology from NITK, with keen interest on innovating critical aspects of commercial scale production of microalgae and developing value-based products. They are developing a novel technique for the algae production which involves producing algae on porous solid substrates. This technique works on the principle of biofilm formation of algal species, which helps the algae grow on vertical surfaces under standard conditions with the right nutrition provided. This technology helps to produce algae in a controlled environment, hence reducing the recourses consumption, contamination issues, capital investment, and increasing productivity by many folds.
Anabio Technologies Pvt Ltd
Anabio Technologies is a startup based out of Bengaluru in the consumer goods and healthcare domain. They are developing self-disintegrable and naturally biodegradable sanitary pad for pit latrines and flushless toilets.
Infection Shield Biotech Pvt Ltd
I-Shield is a Bengaluru based Biotech Start-up developing anti-viral & anti-infection products to mitigate the COVID-19 pandemic. Their proprietary molecule “IS-212”, has demonstrated broad-spectrum bactericidal & virucidal activities, including COVID-19. They have developed tekFABRIK, India’s first facemask to kill 99.99% covid-19. I-Shield is the 1st company in India and 3rd company in the World to achieve this feat. IShield was the first company in India to test its treated fabric for its ability to destroy 99% of Covid-19 virus in under 15 minutes, in an independent study performed by RGCB, Trivandrum. Post successful commercialization of India’s first “Self-Sanitizing” face mask, I-Shield’s team expanded its technology portfolio to addresses “infection control” on surfaces, hands, fabrics and air viz., tekCLEAN, tekRUB, tekWASH. I-Shield is the first company in India to receive regulatory approval (under drug class as external application) to market.
Thanmatra Life Pvt Ltd
Thanmatra Life is an Ernakulam, Kerala based Molecular Bioscience Company developing innovative healthcare products for a safe and healthy living. The company provides total hygiene solutions for a wide range of products across personal healthcare, domestic and institutional applications. Thanmatra Life products are formulated with a unique blend of natural and internationally approved molecules to fight against disease causing bacteria and viruses. Herbal Nuriel Liquid Glove TM, a one of its kind of product will protect hands from germs up to 08 12hrs by forming an invisible thin layer on hands with natural, safe and approved anti-microbial agents.
Plastic, one of the most versatile material ever discovered has become one of the most challenging environmental pollutant. Many recycling options like, mechanical, chemical or thermal, comes with limitations either in the number of recycling, environmental safety or requirement of very high temperatures. The team intend to address this problem using biological tools involving enzymes which can degrade/hydrolyse plastic polymers and enable industrial-scale closed-loop biodegradation and recycling.