Title | Metabolic control of cellular immune-competency by odors in Drosophila [Mass Spectrometry - Metabolomics Facility (INT)] |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Madhwal S, Shin M, Kapoor A, Goyal M, Joshi MK, Rehman PMujeeb Ur, Gor K, Shim J, Mukherjee T |
Journal | Elife |
Volume | 9 |
Date Published | 2020 Dec 29 |
ISSN | 2050-084X |
Abstract | Studies in different animal model systems have revealed the impact of odors on immune cells; however, any understanding on why and how odors control cellular immunity remained unclear. We find that employ an olfactory-immune cross-talk to tune a specific cell type, the lamellocytes, from hematopoietic-progenitor cells. We show that neuronally released GABA derived upon olfactory stimulation is utilized by blood-progenitor cells as a metabolite and through its catabolism, these cells stabilize Sima/HIFα protein. Sima capacitates blood-progenitor cells with the ability to initiate lamellocyte differentiation. This systemic axis becomes relevant for larvae dwelling in wasp-infested environments where chances of infection are high. By co-opting the olfactory route, the preconditioned animals elevate their systemic GABA levels leading to the upregulation of blood-progenitor cell Sima expression. This elevates their immune-potential and primes them to respond rapidly when infected with parasitic wasps. The present work highlights the importance of the olfaction in immunity and shows how odor detection during animal development is utilized to establish a long-range axis in the control of blood-progenitor competency and immune-priming. |
DOI | 10.7554/eLife.60376 |
Alternate Journal | Elife |
PubMed ID | 33372660 |
PubMed Central ID | PMC7808736 |
Grant List | DBT/PR13446/COE/34/30/2015 / / Department of Biotechnology, Ministry of Science and Technology, India / DST/ECR/2015/000390 / / Department of Science and Technology, Ministry of Science and Technology, India / Ramalingaswami Fellowship / / Department of Biotechnology, Ministry of Science and Technology, India / DBT/PR13446/COE/34/30/2015 / / Department of Biotechnology , Ministry of Science and Technology / DST/ECR/2015/000390 / / Department of Science and Technology, Ministry of Science and Technology / Ramalingaswami Fellowship / / Department of Biotechnology , Ministry of Science and Technology / 000390DBT-IYBA 2017 / / DBT-The Innovative Young Biotechnologist Award (IYBA)2017 / CEFIPRA / / Centre Franco-Indien pour la Promotion de la Recherche Avancée / NRF2014S1A2A2028388 / / National Research Foundation / NRF-2017R1C1B2007343 / / National Research Foundation / |
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