@article {1017,
	title = {Comparative analysis of the gut microbiota in centenarians and young adults shows a common signature across genotypically non-related populations [Mass Spectrometry - Metabolomics Facility].},
	journal = {Mech Ageing Dev},
	volume = {179},
	year = {2019},
	month = {2019 Feb 06},
	pages = {23-35},
	abstract = {<p>Gut microbiota is among the factors that may be involved in healthy aging. Broader and geographically spread studies on gut microbiota of centenarians can help in identifying a common signature of longevity. We identified an endogamous Indian population with high centenarian prevalence. Here, we compared the gut microbiota composition and fecal metabolites of a centenarians group (\~{}100 years) with young people (25-45 years) of the region with the high centenarian prevalence and the nearby region of low centenarian prevalence to decipher microbial-related longevity signatures. Also, we compared our results with publicly available datasets of similar groups including 125 centenarians from three countries (Italy, Japan, China). Our comparative analysis resulted in higher biodiversity within Ruminococcaceae in centenarians, with respect to younger adults, irrespective of their nationality. We observed bacterial signatures that are common among extremely old people of different nationality. Comparative metabolites profiling identified the fecal metabolic signature of extreme aging in the Indian study population. Our analysis of the co-occurrence network and bimodal distribution of several taxa suggested the establishment of a pervasive change in the gut ecology during extreme aging. Our study might pave the way to develop gut microbiota based biomarkers for healthy aging.</p>
},
	issn = {1872-6216},
	doi = {10.1016/j.mad.2019.02.001},
	author = {Tuikhar, Ngangyola and Keisam, Santosh and Labala, Rajendra Kumar and Ramakrishnan, Padma and Arunkumar, Moirangthem Cha and Ahmed, Giasuddin and Biagi, Elena and Jeyaram, Kumaraswamy}
}
