@article {504,
	title = {Thioaptamers targeting dengue virus type-2 envelope protein domain III. [Protein Technology Core]},
	journal = {Biochem Biophys Res Commun},
	volume = {453},
	year = {2014},
	month = {2014 Oct 24},
	pages = {309-15},
	abstract = {<p class="rtejustify">Thioaptamers targeting the dengue-2 virus (DENV-2) envelope protein domain III (EDIII) were developed. EDIII, which contains epitopes for binding neutralizing antibodies, is the putative host-receptor binding domain and is thus an attractive target for development of vaccines, anti-viral therapeutic and diagnostic agents. Thioaptamer DENTA-1 bound to DENV-2 EDIII adjacent to a known neutralizing antibody binding site with a dissociation constant of 154nM.</p>
},
	keywords = {Antibodies, Neutralizing, Antiviral Agents, Aptamers, Nucleotide, Base Sequence, Dengue Virus, Magnetic Resonance Spectroscopy, Viral Envelope Proteins},
	issn = {1090-2104},
	doi = {10.1016/j.bbrc.2014.09.053},
	author = {Gandham, Sai Hari A and Volk, David E and Lokesh, Ganesh L R and Neerathilingam, Muniasamy and Gorenstein, David G}
}
