@article {8125,
	title = {Conformationally restricted, dipeptide-based, self-assembled nanoparticles for efficient vancomycin delivery. [C-CAMP BIG Grantee/Startup]},
	journal = {Nanomedicine (Lond)},
	year = {2023},
	month = {2023 Jan 16},
	type = {Journal Article},
	abstract = {<p>Emergence of vancomycin (Van) resistance, and usage of its higher dose and short half-life are posing a serious concern. Slow and sustained release of Van using a nanodelivery system may overcome these problems. Arginine-α,β-dehydrophenylalanine (RΔF) was synthesized using solution-phase synthesis which self-assembled into nanospheres. Van was entrapped in the nanoparticles (NPs). and efficacy of Van-RΔF was determined using broth microdilution and the mouse thigh infection model, respectively. Van-RΔF NPs efficiently inhibited bacterial growth (), while Van alone showed limited growth inhibition in . Intravenous administration of Van-RΔF in mice with bacterial thigh infection showed enhanced efficacy (double) compared with Van alone, which indicates its high potential for further development.</p>
},
	keywords = {antibiotic delivery, nanostructures, self-assembly, sustained release, ultrashort peptides},
	issn = {1748-6963},
	doi = {10.2217/nnm-2022-0144},
	url = {https://www.futuremedicine.com/doi/abs/10.2217/nnm-2022-0144},
	author = {Yadav, Nitin and Kumar, Utkarsh and Chauhan, Virander Singh}
}
